Toll-Like Receptor 11
Lambert M. SurhoneISBN: 978-3-6399-9462-9;
Toll-like receptor 11 (TLR 11) is a protein encoded by the gene TLR11. TLR 11 belongs to the Toll-like receptor (TLR) family and the Interleukin-1 receptor/Toll-like receptor superfamily. By recognizing molecular patterns present on microbes, it helps propagate a host immune response. TLR 11 plays a fundamental role in both the innate and adaptive immune responses, through the activation of Tumor necrosis factor-alpha, the Interleukin 12 (IL-12) response, and Interferon-gamma (INF-gamma) secretion. TLR 11 specifically mounts an immune response to two different microbes: Toxoplasma gondii (T. gondii) and uropathogenic Escherichia coli (E. coli).
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