Lambert M. SurhoneISBN: 978-6-1324-9981-3;
The Pre-Botzinger Complex (preBotC) is a cluster of interneurons in the ventrolateral medulla of the brainstem, which is essential to the generation of respiratory rhythm in mammals. The exact mechanism of the rhythm generation and transmission to motor nuclei remains controversial and the topic of much present research. Several synthetic compounds have been shown to act on neurons specific to the preBotC, most being selective agonists or antagonists to receptor subtypes on neurons in the vicinity. Since many of these neurons express GABA, glutamate, serotonin and adenosine receptors, chemicals custom tailored to bind at these sites are most effective at altering respiratory rhythm. One such novel compound that acts on this area of the brain, called BIMU8, has been discovered.
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