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NS1 Influenza Protein

ISBN: 978-6-1320-0475-8;

end. NS1 forms a dimer that inhibits the export of poly(A) containing mRNA molecules from the nucleus. This gives preference to viral RNA. NS1 might also inhibit splicing of pre-mRNA by binding to a stem-bulge region in U6 small nuclear RNA (snRNA). In addition, NS1 is probably able to suppress the interferon response in the virus-infected cell leading to unimpaired virus production.

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